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The Progenitors The Progenitors 1
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Book Synopsis The Regulation and Function of Hematopoietic Progenitor Kinase-1 in Antigen Receptor Signal Transduction by : Jen Liou
Download or read book The Regulation and Function of Hematopoietic Progenitor Kinase-1 in Antigen Receptor Signal Transduction written by Jen Liou and published by . This book was released on 2001 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Hematopoietic Progenitors in Immune Regulation and Memory by : Flora Zavala
Download or read book The Role of Hematopoietic Progenitors in Immune Regulation and Memory written by Flora Zavala and published by Frontiers Media SA. This book was released on 2022-01-07 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proceedings of the Academy Workshop on Supernovae, Their Progenitors and Remnants, October 29-November 2, 1984, Raman Research Institute, Bangalore by : Ganesan Srinivasan
Download or read book Proceedings of the Academy Workshop on Supernovae, Their Progenitors and Remnants, October 29-November 2, 1984, Raman Research Institute, Bangalore written by Ganesan Srinivasan and published by . This book was released on 1985 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progenitor and Stem Cell Technologies and Therapies by : Anthony Atala
Download or read book Progenitor and Stem Cell Technologies and Therapies written by Anthony Atala and published by Elsevier. This book was released on 2012-03-15 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progenitor and stem cells have the ability to renew themselves and change into a variety of specialised types, making them ideal materials for therapy and regenerative medicine. Progenitor and stem cell technologies and therapies reviews the range of progenitor and stem cells available and their therapeutic application. Part one reviews basic principles for the culture of stem cells before discussing technologies for particular cell types. These include human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells. Part two discusses wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies. The final part of the book considers the therapeutic use of stem and progenitor cells. Chapters review the use of adipose tissue-derived stem cells, umbilical cord blood (UCB) stem cells, bone marrow, auditory and oral cavity stem cells. Other chapters cover the use of stem cells in therapies in various clinical areas, including lung, cartilage, urologic, nerve and cardiac repair. With its distinguished editor and international team of contributors, Progenitor and stem cell technologies and therapies is a standard reference for both those researching in cell and tissue biology and engineering as well as medical practitioners investigating the therapeutic use of this important technology. Reviews the range of progenitor and stem cells available and outlines their therapeutic application Examines the basic principles for the culture of stem cells before discussing technologies for particular cell types, including human embryonic, induced pluripotent, amniotic and placental, cord and multipotent stem cells Includes a discussion of wider issues such as intellectual property, regulation and commercialisation of stem cell technologies and therapies
Book Synopsis Characterization of Resident Sca-1 Progenitor Cells in the Failing Murine Heart by : Rasmita Samal
Download or read book Characterization of Resident Sca-1 Progenitor Cells in the Failing Murine Heart written by Rasmita Samal and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stem Cells and Progenitors in Liver Development by : Marcus O. Muench
Download or read book Stem Cells and Progenitors in Liver Development written by Marcus O. Muench and published by Morgan & Claypool Publishers. This book was released on 2012-12-01 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human liver is a dynamic organ throughout life, but no more so than during prenatal development. The liver performs many essential functions associated with metabolism, immunity and blood production. These diverse functions are performed by a variety of cell types that have the capacity for growth, allowing the liver to regenerate cells lost due to aging, infection or injury. Various stem cell populations are at the core of the liver's potential for regeneration, which are most active during embryonic and fetal development, when the liver undergoes rapid growth. Consequently, the prenatal liver represents a unique opportunity to study the precursor cells that give rise to all liver cells at their time of greatest activity. Herein, we focus on the early development of the human liver from the perspective of the stem cells and their many lines of progeny that generate the hepatic, endothelial, mesenchymal and hematopoietic cells that comprise the fetal liver. Understanding the developmental relationships, growth control and cellular interactions among these cells is crucial to our understanding of liver development and function during prenatal life. This knowledge also provides insight into the development of cellular therapies, transplantation and the treatment of cancers.
Book Synopsis Human Induced Pluripotent Stem Cells as a Source for Cardiovascular Progenitors Marked by the Transcription Factor ISLET 1 by : Tu-Mai Juliane Thies
Download or read book Human Induced Pluripotent Stem Cells as a Source for Cardiovascular Progenitors Marked by the Transcription Factor ISLET 1 written by Tu-Mai Juliane Thies and published by . This book was released on 2011 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Impact of HIV-1 on Hematopoietic Stem and Progenitor Cells by : Sebastian Renelt
Download or read book The Impact of HIV-1 on Hematopoietic Stem and Progenitor Cells written by Sebastian Renelt and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Caveolin-1 Is a Negative Regulator of Neuronal Differentiation of Neural Progenitor Cells in Vitro and in Vivo by : Yue Li
Download or read book Caveolin-1 Is a Negative Regulator of Neuronal Differentiation of Neural Progenitor Cells in Vitro and in Vivo written by Yue Li and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Caveolin-1 is a Negative Regulator of Neuronal Differentiation of Neural Progenitor Cells in Vitro and in Vivo" by Yue, Li, 李越, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b4691886 Subjects: Membrane proteins Neural stem cells
Book Synopsis Stem Cells and Progenitor Cells in Ischemic Stroke - Fashion or Future? by : Thorsten R. Doeppner
Download or read book Stem Cells and Progenitor Cells in Ischemic Stroke - Fashion or Future? written by Thorsten R. Doeppner and published by Frontiers Media SA. This book was released on 2016-01-15 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke remains one of the most devastating diseases in industrialized countries. Recanalization of the occluded arterial vessel using thrombolysis is the only causal therapy available. However, thrombolysis is limited due to severe side effects and a limited time window. As such, only a minority of patients receives this kind of therapy, showing a need for new and innovative treatment strategies. Although neuroprotective drugs have been shown to be beneficial in a variety of experimental stroke models, they ultimately failed in clinical trials. Consequently, recent scientific focus has been put on modulation of post-ischemic neuroregeneration, either via stimulation of endogenous neurogenesis or via application of exogenous stem cells or progenitor cells. Neurogenesis persists within the adult brain of both rodents and primates. As such, neural progenitor cells (NPCs) are found within distinct niches like the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus. Cerebral ischemia stimulates these astrocyte-like progenitor cells, upon which NPCs proliferate and migrate towards the site of lesion. There, NPCs partly differentiate into mature neurons, without significantly being integrated into the residing neural network. Rather, the majority of new-born cells dies within the first weeks post-stroke, leaving post-ischemic neurogenesis a phenomenon of unknown biological significance. Since NPCs do not replace lost brain tissue, beneficial effects observed in some studies after either stimulated or protected neurogenesis are generally contributed to indirect effects of these new-born cells. The precise identification of appropriated cellular mediators, however, is still elusive. How do these mediators work? Are they soluble factors or maybe even vesicular structures emanating from NPCs? What are the cues that guide NPCs towards the ischemic lesion site? How can post-ischemic neurogenesis be stimulated? How can the poor survival of NPCs be increased? In order to support post-ischemic neurogenesis, a variety of research groups have focused on application of exogenous stem/progenitor cells from various tissue sources. Among these, cultivated NPCs from the SVZ and mesenchymal stem cells (MSCs) from the bone marrow are frequently administered after induction of stroke. Although neuroprotection after delivery of stem/progenitor cells has been shown in various experimental stroke models, transplanted cells are usually not integrated in the neural network. Again, the vast amount of grafted cells dies or does not reach its target despite profound neuroprotection, also suggesting indirect paracrine effects as the cause of neuroprotection. Yet, the factors being responsible for these observations are under debate and still have to be addressed. Is there any “optimal” cell type for transplantation? How can the resistance of grafted cells against a non-favorable extracellular milieu be increased? What are the molecules that are vital for interaction between grafted cells and endogenous NPCs? The present research topic seeks to answer - at least in part - some of the aforementioned questions. Although the research topic predominantly focuses on experimental studies (and reviews alike), a current outlook towards clinical relevance is given as well.
Book Synopsis Longitudinal Characterization of the Mesenchymal Progenitor Cell Phenotype of Sca-1/Ly6A Null Mice by : Christina Holmes
Download or read book Longitudinal Characterization of the Mesenchymal Progenitor Cell Phenotype of Sca-1/Ly6A Null Mice written by Christina Holmes and published by . This book was released on 2006 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell antigen-1 (Sca-1/Ly6A) is a GPI-AP expressed by a variety of stem cell populations. Previous studies involving Sca-1 knockout (KO) mice revealed an age-related osteoporotic phenotype, characterized by decreased bone mass and bone brittleness, due to mesenchymal progenitor defects. In this study, the in vitro mesenchymal progenitor cell phenotype of Sca-1-/- mice and wild type BALB/ c controls was characterized at 3, 5, 7, 9 and 12 months of age. A significant defect in osteo-, adipo- and total mesenchymal progenitors in Sca-1-/- mice was found to arise between 5 and 7 months of age, as measured by the CFU-A, CFU-ALP/O, and CFU-F assays, persisting until at least 12 months. These defects encompass progenitor self-renewal, expansion, and potentially osteogenic and adipogenic differentiation. These results provide the baseline parameters enabling the use of Sca-1-/- mice in future studies as model of age-related osteoporosis.
Book Synopsis Myeloid Progenitor Cells—Advances in Research and Application: 2013 Edition by :
Download or read book Myeloid Progenitor Cells—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myeloid Progenitor Cells—Advances in Research and Application: 2013 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about ZZZAdditional Research in a compact format. The editors have built Myeloid Progenitor Cells—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Myeloid Progenitor Cells—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Neural Development and Regeneration by : A. Gorio
Download or read book Neural Development and Regeneration written by A. Gorio and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data of all relevant aspects of neuronal cell growth and differentiation are presented in this volume. Regulation of expression, storage and release of nerve growth factors, receptor control and the cellular responses to growth factors are comprehensively discussed. Treated are also influences of various neurotransmitters on neuronal morphogenesis and new results of interactions of cells and mediators of the immune, endocrine and nervous system. Special emphasis is given to those factors regulating regeneration and nerve spreading after injuries of the nerve tissue.
Book Synopsis Proceedings of the Graduate Academy of the University of California by : Graduate Academy of the University of California
Download or read book Proceedings of the Graduate Academy of the University of California written by Graduate Academy of the University of California and published by . This book was released on 1963 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of CXCR4 and SDF-1 in Hematopoietic Stem and Progenitor Cell Function [microform] by : Michael D. (Michael David) Rosu-Myles
Download or read book Characterization of CXCR4 and SDF-1 in Hematopoietic Stem and Progenitor Cell Function [microform] written by Michael D. (Michael David) Rosu-Myles and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cells (HSC) are defined by a capacity for self-renewal and the ability to form all cells comprising the blood. Chemokines regulate the proliferation and migration of lineage restricted hematopoietic progenitors and are, thus, candidate molecules for regulating HSC function. The studies presented here examined the potential role of the chemokine SDF-1 and its putative receptor, CXCR4, on human hematopoietic progenitors and HSC and in the migration of primitive blood cells to the skeletal muscle hematopoietic site. By screening a panel of chemokine receptors whose ligands have been implicated in the regulation of blood progenitors, CXCR4 was identified as a predominate receptor expressed on rare, stem cell enriched, populations throughout human ontogeny. In vitro and in vivo functional assays demonstrated that CXCR4 is expressed only on a fraction of primitive blood progenitors and candidate human HSC with bone marrow (BM) repopulating capacity (SRC). CXCR4+ and CXCR4- SRC had the identical proliferative potential and multipotent differentiation capacity upon i.v. transplantation into NOD/SCID mice and engrafted similar tissue sites including the BM and skeletal muscle. To gain insight into the potential function of SDF-1 and CXCR4, serum free cultures and transwell assays were used to characterize the effects of this receptor/ligand pair on the proliferation of human blood progenitors and the migration of murine BM cells in response to skeletal myofibers. SDF-1 alone promoted the survival of human hematopoietic progenitors and enhanced their expansion in synergy with the growth factors, stem cell factor (SCF) and Flt-3. In transwell assays, SDF-1 and CXCR4 regulated the migration of hematopoietic progenitors to BM stroma but not towards myofibers. Instead, migration of primitive blood cells towards muscle was inhibited by blocking the hepatocyte growth factor (HGF) receptor, c-met. The work presented here identifies novel CXCR4+ and CXCR4- stem cell subsets in the human and suggests that CXCR4 and SDF-1 are not critical to BM repopulating function but can augment the proliferation and survival of lineage restricted hematopoietic progenitors. In addition, this work demonstrates that HGF induced migration is an alternative mechanism of progenitor cell motility and identifies distinct populations of hematopoietic progenitors in the BM that migrate in response to either SDF-1 or HGF. Taken together the data suggests a relationship between CXCR4 and c-met expression and the migration of primitive blood cells between the BM and skeletal muscle.
Book Synopsis Controlled Generation of Progenitor T-cells from Hematopoietic Stem Cells and Pluripotent Stem Cells by : Shreya Shukla
Download or read book Controlled Generation of Progenitor T-cells from Hematopoietic Stem Cells and Pluripotent Stem Cells written by Shreya Shukla and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thymus integrates multiple niche molecules including cytokines, ligands and extracellular matrix to drive T-cell development in vivo. We hypothesized that engineering technologies to integrate essential thymic niche molecules required for progenitor T-cell development would enable defined in vitro generation and quantification of T-cells. We optimized a defined 2D serum-free culture system using Notch ligand Delta-like-4 (DL4) for producing progenitor T-cells from mouse Sca-1+cKit+ hematopoietic stem and progenitor cells (HSPCs). Serum-free culture enabled us to define assay design criteria such as input cell density, DL4 presentation and cytokine concentrations. The fully defined engineered in vitro niche revealed synergistic interactions between DL4 and vascular cell adhesion molecule-1 (VCAM-1), and its role in enhancing downstream Notch pathway activation, progenitor T-cell migration and differentiation. The engineered niche also enabled scalable differentiation of human umbilical cord blood-derived CD34+ HSPCs to CD7+ progenitor T-cells, yielding 25-fold total cell expansion with 59.3±10.8% CD7+ T-cells. CD7+ progenitor T-cells generated in the engineered niche were capable of thymic engraftment in lymphodeficient SIRPa-/- Rag2-/- gc-/- mice and generated mature functional CD3+ T-cells in vivo. Building on this system, we next immobilized DL4 in a 3D methylcellulose hydrogel (DL4-MC) using thiol-maleimide chemistry. DL4-MC hydrogels exhibited a dose-dependent increase in Notch pathway activation. We demonstrated that production of progenitor T-cells from HSPCs encapsulated in DL4-MC hydrogels could be enhanced when VCAM-MC was incorporated, creating a 3D engineered hydrogel thymus-like niche. Thus, controlled and reproducible differentiation of progenitor T-cells from stem cells can be achieved by engineering a thymus-like niche in vitro using minimum essential cues required for T-cell development. This provides an important step towards systematically engineering the niche for progenitor T-cell development with the ultimate goal of generating histocompatible "off-the-shelf" T-cells from normal or gene-edited stem cells for T-cell immunotherapeutic applications.
Book Synopsis Pim-1 is Expressed in Cardiac Progenitor Cells and Stimulates Progenitor Cell Proliferation by : Christopher Travis Cottage
Download or read book Pim-1 is Expressed in Cardiac Progenitor Cells and Stimulates Progenitor Cell Proliferation written by Christopher Travis Cottage and published by . This book was released on 2008 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: